Current Projects Recent Papers Research Team Formal Projects

 

to support our Research improving outcomes for the critically ill – choose Intensive Care in the Campaign list.

2018

Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions (Dr Jayesh Dhanani, A/Prof Jeremy Cohen, Prof Jeffrey Lipman, Dr Jason Roberts)

A comparison between raw and predicted mortality in a paediatric intensive care unit in South Africa (Prof Jeffrey Lipman)

A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminaemia receiving continuous venovenous haemodiafiltration (Janine Stuart, Jenie Butler, Therese Starr, Prof Jeffrey Lipman, Dr Jason Roberts)

Ex Vivo Characterization of Effects of Renal Replacement Therapy Modalities and Settings on Pharmacokinetics of Meropenem and Vaborbactam (Prof Jeffrey Lipman, Dr Jason Roberts)

Patient and family engagement in the ICU: Report from the task force of the World Federation of Societies of Intensive and Critical Care Medicine (Prof Jeffrey Lipman)

Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem: a comparison of eight pharmacokinetic models (Dr Jason Roberts)

The Statistical Curriculum Within Randomized Controlled Trials in Critical Illness (Prof Jeffrey Lipman)

Therapeutic drug monitoring of β-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures (Prof Jeffrey Lipman, Dr Jason Roberts)

A Robust Statistical Approach to Analyse Population Pharmacokinetic Data in Critically Ill Patients Receiving Renal Replacement Therapy (Prof Jeffrey Lipman, Dr Jason Roberts)

New paradigm for rapid achievement of appropriate therapy in special populations: coupling antibiotic dose optimization rapid microbiological methods (Prof Jeffrey Lipman, Dr Jason Roberts)

A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models (Dr Jayesh Dhanani, A/Prof Jeremy Cohen, Prof Jeffrey Lipman, Dr Jason Roberts)

Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem: a comparison of eight pharmacokinetic models (Prof Jeffrey Lipman, Dr Jason Roberts)

The effects of normovolemic anemia and blood transfusion on cerebral microcirculation after severe head injury (Dr Judith Bellapart)

Optimised dosing of vancomycin in critically ill Indigenous Australian patients with severe sepsis (Prof Jeffrey Lipman, Dr Jason Roberts)

Population pharmacokinetics of vancomycin in critically ill patients receiving prolonged intermittent renal replacement therapy (Prof Jeffrey Lipman, Dr Jason Roberts)

Predictive performance of a gentamicin population pharmacokinetic model in two western populations of critically ill patients (Dr Jason Roberts)

Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury (Dr John Gowardman, Prof Jeffrey Lipman, Dr Jason Roberts)

Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis (A/Prof Jeremy Cohen)

Audit of ten years of donation after circulatory death experience in Queensland: observations of agonal physiology following withdrawal of cardiorespiratory support (Dr Neil Widdicombe)

Pharmacokinetics of Intravenous Posaconazole in Critically Ill Patients (Janine Stuart, Jenie Butler, Therese Starr, Prof Jeffrey Lipman, Dr Jason Roberts)

Cerebral Microcirculation and Histological Mapping After Severe Head Injury: A Contusion and Acceleration Experimental Model (Dr J Bellapart)

Pharmacokinetics of piperacillin in critically ill patients with acute kidney injury receiving sustained low-efficiency diafiltration (Prof Jeffrey Lipman, Dr Jason Roberts)

Utility of community-acquired pneumonia severity scores in guiding disposition from the emergency department: Intensive care or short-stay unit? (Prof Jeffrey Lipman)

Individualising Therapy to Minimize Bacterial Multidrug Resistance (Prof Jeffrey Lipman, Dr Jason Roberts)

Antibiotic Distribution into Cerebrospinal Fluid: Can Dosing Safely Account for Drug and Disease Factors in the Treatment of Ventriculostomy-Associated Infections? (Prof Jeffrey Lipman, Dr Jason Roberts)

Characteristics, treatment and outcomes for all emergency department patients fulfilling criteria for septic shock: a prospective observational study (Prof Jeffrey Lipman)

Clinical application of microsampling versus conventional sampling techniques in the quantitative bioanalysis of antibiotics: a systematic review (Prof Jeffrey Lipman, Dr Jason Roberts)

Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli (Prof Jeffrey Lipman, Dr Jason Roberts)

Impact of Quality Bundle Enforcement by a Critical Care Pharmacist on Patient Outcome and Costs (Dr Jason Roberts)

Beta-Lactam Therapeutic Drug Monitoring in the Critically Ill Children: Big Solution for Infections in Small People? (Dr Jason Roberts)

Prevalence of augmented renal clearance and performance of glomerular filtration estimates in Indigenous Australian patients requiring intensive care admission (Prof Jeffrey Lipman, Dr Jason Roberts)

Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (A/Prof Jeremy Cohen) – A/Prof Cohen recommends also reading the appendix.

Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi‑drug resistance (Prof Jeffrey Lipman, Dr Jason Roberts)

Maximally effective dosing regimens of meropenem in patients with septic shock (Prof Jeffrey Lipman, Dr Jason Roberts)

A UHPLC–MS/MS method for the simultaneous determination of piperacillin and tazobactam in plasma (total and unbound), urine and renal replacement therapy effluent (Prof Jeffrey Lipman, Dr Jason Roberts)

The effects of major burn related pathophysiological changes on the pharmacokinetics and pharmacodynamics of drug use: An appraisal utilizing antibiotics (Prof Jeffrey Lipman, Dr Jason Roberts)

 

Archive

Papers published in 2017