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to support our Research improving outcomes for the critically ill – choose Intensive Care in the Campaign list.

 

Studies in active recruitment

Study PI
BLING IIIA phase III randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients Lipman
Ceftriaxone HREC/16/QRBW/101Optimising ceftriaxone dosing for critically ill patients with severe pneumoniaCotta, Roberts
Ceftolozane/Tazobactam HREC/16/QRBW/211 An Observational Pharmacokinetic sudy of Ceftolozane-Tazobactam in Intensive Care Unit in patients with and without continuous renal replacement therapy.Roberts
Ceftolozane/Tazobactam HREC/17/QRBW/117“A prospective observational pharmacokinetic evaluation of the plasma and cerebrospinal fluid concentrations of a single dose ceftolozane/tazobactam in infected critically ill patients with an indwelling external ventricular drain”Roberts, Lipman
10-10Validation of a 10 minute spontaneous breathing trial to predict time to circulatory death in organ donation candidatesWiddicombe
Feisty JuniorFibrinogen Concentrate vs. Cryoprecipitate in under 18 year olds.Holley
GUPPIE HREC/16/QRBW/263 An Observational Study to assess aspiration risk using gastric ultrasound in ventilated ICU patients prior to extubationO'Donoghue, Roach
Micro sampling HREC/15/QRBW/249Validation of microsampling versus traditional blood sampling for antibiotic pharmacokinetics.Lipman, Wallis
Nicotine study HREC17/QTPCH/492Pharmacokinetics of Transdermal Nicotine replacement thereapy patches in the ICU: A prospective observational pharmacokinetic study of nicotine/cotinine concentrations in critically ill smokers receiving transdermal NRT patchesCohen, Lui
OASES EVD sampling for antibiotics HREC/16/QRBW/157The Pharmacokinetics of Ceftriaxone, Meropenem, Piperacillin-Tazobactam and Vancomycin in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed MeningesRoberts, Kumta
PATCH TRAUMA HREC/14/QRBW/501Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study) A multi-centre randomised, double-blind, placebo-controlled trial of pre-hospital treatment with tranexamic acid for severely injured patients at risk of acute traumatic coagulopathy.Reade, Holley
PLUS HREC/16/HAWKE/126A multi-centre, blinded, randomised, controlled trial (RCT) to determine whether fluid resuscitation and therapy with a “balanced” crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality in critically ill patients requiring fluid resuscitation when compared to the same treatment with 0.9% sodium chloride (saline)Lipman
Pneumo-INSPIRE HREC/15/QRBW/35International Study on NoSocomial Pneumonia in Intensive CarE An international multi-centre prospective observational cohort study of nosocomial pneumonia in intensive care unitsKoulenti
Pseudomonas in Burns HREC/17/other/24Evolution of Beta lactam reistance in pseudomonas aeruginosa during treatment of major burn injuryLipman, Heney
The SYNAPSE-ICU StudyInternational prospective observational StudY on iNtrAcranial PreSsurE in intensive care (ICU)Reade, Fourie
RESIST HREC/15/QRBW/28 Recognising Sepsis in SIRS Trial (RESIST)Denny
RESTOREA Phase III, Randomized, Double-Blind, Active Comparator-Controlled Clinical Trial to Study the Safety, Tolerability, and Efficacy of Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Subjects with Hospital-Acquired Bacterial Pneumonia or Ventilator-Associated Bacterial PneumoniaLipman, Roberts
SOFIA (Anaetnetics)Microcirculatory DySfunction and Skin Failure in Critically Ill patients: An exploratory studyDalgleish, Coyer
TAME Cardiac ArrestTargeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest A Phase III Multi-Centre Randomised Controlled TrialLipman, Reade
TARGET- Point prevalenceHREC/18/CALHN/443 Nutrition prescription in Australian and New Zealand intensive care units: A point-prevalence auditLipman
TASTE HREC/15/QRBW/372A Potential Taste Receptor Association with Myocardial Depression Susceptibility in Treated sEpsisPresneill, Lipman, Thomas
TBI Study HREC/14/QRBW/7A Comparison of the Total and Free Cortisol Response to a Standard Short Synacthen Test in Patients with Traumatic Brain InjuryCohen
XANTHO HREC/17/QRBW/218Timing of Lumbar puncture for the setection of xanthochromia in subarachnoid haemorrhageChu

Pending publication – recruitment complete

Study PI
Colonic Flora HREC/16/QRBW/463 Assessing the effects of antibiotic choice on gut microbiota of ICU pts - a metagenomic apprachPaterson, Harris, Schlebusch
ENDO 2 HREC/14/QRBW/4The prognostication value of plasma Endothelin-1 in sub arachnoid HaemorrhageBellapart
FEIStyFibrinogen Concentrate vs. Cryoprecipitate in Traumatic Haemorrhage: A Pilot Randomised Controlled TrialDEM with ICU assistance
LEVETY HREC/16/QRBW/154Levetiracetam pharmacokinetics in critically ill patients with severe traumatic brain injury and subarachnoid haemorrhageCotta, Roberts
LINC BBurns unit- not ICU PLASMA AND TISSUE PHARMACOKINETICS OF LINCOMYCIN IN PATIENTS WITH BURN WOUND INFECTIONRoberts, Wang
Microscan HREC/08/QRBW/112Assessment of the Microcirculation in Shocked Critically Unwell Patients during the First 24 hours of ResuscitationHolley
PROMOTE-aSAH HERC/16/QRBW/204A prospective multicentre observational study of aneurysmal subarachnoid haemorrhage in Australasian intensive care The PROMOTE-SAH StudyCohen, Udy
SAFE -ICU (HREC/16/QRBW/292)Screening Anti-Fungal Exposure in Intensive Care Units The SAFE-ICU Study An international, multi-centre prospective pharmacokinetic evaluation of antifungal drug exposure in intensive care unit patients receiving conventional dosing regimensRoberts, Roger
SPICE III HREC/12/AUSTIN/108Early Goal Directed Sedation vs. Standard Care Sedation Sedation Practices in Intensive Care Evaluation: SPICE III: A Prospective Multicentre Randomised Controlled Trial of Early Goal Directed Sedation Compared with Standard Care in Mechanically Ventilated Patients in Intensive CareO'Donoghue
TAK-954 (Takeda)Phase 2b, Randomized, Multi-Center, Double-Blind, Dose-Ranging Study to Assess the Efficacy, Safety, and Pharmacokinetics of Intravenous TAK-954 in Critically Ill Patients with Enteral Feeding IntoleranceReade, Lipman
ALL SPICE HREC/16/QPCH/141Allostasis and Sedation Practices in Intensive Care Evaluation (All-SPICE)Reade
National study of family experiences of organ and tisue donationData exchange study -follow up of families who declined organ donationWiddicombe

For more information about our studies, please email our Research team