Current Projects Recent Papers Research Team Formal Projects

research02

to support our Research improving outcomes for the critically ill – choose Intensive Care in the Campaign list.

Study PI
ABSES HREC/15/QRBW/631The Abdominal Sepsis Study: Epidemioplogy of Etiology and OutcomeKoulenti, Blot
ADRENAL HREC/11/QPAH/619ADjunctive coRticosteroid trEatment iN criticAlly ilL patients with septic shock Cohen
ADP Trauma HREC/15/QRBW/14A randomised controlled clinical trial of Augmented Dosing of Piperacillin-tazobactam in TRAUMA patients with suspected or confirmed infectionUdy, Roberts, Lipman
AMIINO III HREC/16/QRBW/205An international survey on aminoglycoside practices in critically ill patients: AMINO III surveyRoberts, Roger
ARTISAN 123 HREC/13/QRBW/14A RANDOMIZED, DOUBLE–BLIND, PLACEBO–CONTROLLED, PHASE 3 STUDY TO ASSESS THE SAFETY AND EFFICACY OF ART-123 IN SUBJECTS WITH SEVER SEPSIS AND COAGULOPATHYGowardman
Benzylpenicillin HREC/15/QRBW/31Optimising benzylpenicillin dosing for critically ill patients with severe pneumoniaCotta, Roberts
Ceftriaxone HREC/16/QRBW/101Optimising ceftriaxone dosing for critically ill patients with severe pneumoniaCotta, Roberts
Ceftolozane/Tazobactam HREC/16/QRBW/211 An Observational Pharmacokinetic sudy of Ceftolozane-Tazobactam in Intensive Care Unit in patients with and without continuous renal replacement therapy.Roberts
Clexane and Medical ImagingEnoxaparin for Postoperative Prophylaxis in Intracranial Coiling and Stents (EPPICS): A randomized trial of low molecular weight heparin and unfractionated heparin for prevention of arterial thromboembolic complications after endovascular intracranial aneurysm treatmentHocking
CLIP HREC/13/QRBW/3CLIP Cryopreserved vs. Liquid Platelets for Surgical Bleeding A pilot multicentre blinded randomised controlled clinical trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of post-surgical bleeding.Reade
Cubist VAP (ASPECT) HREC/14/QRBW/165A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, MULTICENTER, PHASE 3 STUDY TO ASSESS THE SAFETY AND EFFICACY OF INTRAVENOUS CEFTOLOZANE/TAZOBACTAM COMPARED WITH MEROPENEM IN ADULT PATIENTS WITH VENTILATED NOSOCOMIAL PNEUMONIAGowardman
Da-Vinci HREC/15/QRBW/437Detailed assessment of risks and benefits of inferior vena cava filters on patients with complicated injuries (the da Vinci Trial)Holley
Distinct Coyer
ENACTLow molecular weight heparin in critically ill trauma patients: a dosing study. do not addO'Donoghue
ENDO 2 HREC/14/QRBW/4The prognostication value of plasma Endothelin-1 in sub arachnoid HaemorrhageBellapart
eStimCycleParatz
Extreme Pressure II StudyExploring critically ill patient's tissue in real time in different body positionsCoyer
FEIStyFibrinogen Concentrate vs. Cryoprecipitate in Traumatic Haemorrhage: A Pilot Randomised Controlled TrialDEM with ICU assistance
HREC/16/QRBW/263 GUPPIEAn Observational Study to assess aspiration risk using gastric ultrasound in ventilated ICU patients prior to extubationO'Donoghue, Roach
GhoST HREC/16/QRBW/272A pilot cohort study of endothelial Glycocalyx shedding in Severe Trauma patients – mediator of poor outcomes or marker of resuscitation efficacy? Milford
La Jolla Athos 3A Phase 3, Placebo-Controlled, Randomized, Double-Blind, Multi- Center Study of LJPC-501 in Patients with Catecholamine-Resistant Hypotension (CRH)Cohen
LEVETY HREC/16/QRBW/154Levetiracetam pharmacokinetics in critically ill patients with severe traumatic brain injury and subarachnoid haemorrhageCotta, Roberts
LINC BBurns unit- not ICU PLASMA AND TISSUE PHARMACOKINETICS OF LINCOMYCIN IN PATIENTS WITH BURN WOUND INFECTIONRoberts, Wang
MelatoninEXOGENOUS MELATONIN IN CRITICALLY ILL PATIENTS: THE IMPACT ON SLEEP AND ICU PSYCHOSISBellapart
Microscan HREC/08/QRBW/112Assessment of the Microcirculation in Shocked Critically Unwell Patients during the First 24 hours of ResuscitationHolley
Micro sampling HREC/15/QRBW/249VALIDATION OF MICROSAMPLING VERSUS TRADITIONAL BLOOD SAMPLING FOR ANTIBIOTIC PHARMACOKINETICSLipman, Wallis
OASES EVD sampling for antibiotics HREC/16/QRBW/157The Pharmacokinetics of Ceftriaxone, Meropenem, Piperacillin-Tazobactam and Vancomycin in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed MeningesRoberts, Kumta
PATCH TRAUMA HREC/14/QRBW/501Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study) A multi-centre randomised, double-blind, placebo-controlled trial of pre-hospital treatment with tranexamic acid for severely injured patients at risk of acute traumatic coagulopathy.Reade, Holley
PLUS (HREC/16/HAWKE/126)A multi-centre, blinded, randomised, controlled trial (RCT) to determine whether fluid resuscitation and therapy with a “balanced” crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality in critically ill patients requiring fluid resuscitation when compared to the same treatment with 0.9% sodium chloride (saline)Lipman
Pneumo-INSPIRE HREC/15/QRBW/35International Study on NoSocomial Pneumonia in Intensive CarE An international multi-centre prospective observational cohort study of nosocomial pneumonia in intensive care unitsKoulenti
Posaconazole( HREC/16/QRBW/377)Single dose population pharmacokinetics of intravenous posaconazole in critically ill patientsRoberts
PROMOTE-aSAH (HERC/16/QRBW/204)A prospective multicentre observational study of aneurysmal subarachnoid haemorrhage in Australasian intensive care The PROMOTE-SAH StudyCohen, Udy
REACT-SHOCK HREC/13/HNE/263RELATIVE HYPOTENSION AND ACUTE KIDNEY INJURY IN PATIENTS WITH SHOCK: A PROSPECTIVE MULTICENTER COHORT STUDYO'Donoghue (Udy)
REMedyRCT to testing interventions to reduce NGT and ETT device-related pressure injuries Coyer
RESIST HREC/15/QRBW/28 Recognising Sepsis in SIRS Trial (RESIST)Denny
SAFE -ICU (HREC/16/QRBW/292)Screening Anti-Fungal Exposure in Intensive Care Units The SAFE-ICU Study An international, multi-centre prospective pharmacokinetic evaluation of antifungal drug exposure in intensive care unit patients receiving conventional dosing regimensRoberts, Roger
SMARRTACTRN12613000241730Roberts
SPICE III HREC/12/AUSTIN/108Early Goal Directed Sedation vs. Standard Care Sedation Sedation Practices in Intensive Care Evaluation: SPICE III: A Prospective Multicentre Randomised Controlled Trial of Early Goal Directed Sedation Compared with Standard Care in Mechanically Ventilated Patients in Intensive CareO'Donoghue
ALL SPICE (HREC/16/QPCH/141)Allostasis and Sedation Practices in Intensive Care Evaluation (All-SPICE)Reade
TARGET (HREC/14/RAH/565)TARGET NUTRITION STUDY -The Augmented versus Routine approach to Giving Energy Trial: A randomised controlled trialLipman, Saba
TASTE HREC/15/QRBW/372A Potential Taste Receptor Association with Myocardial Depression Susceptibility in Treated sEpsisPresneill, Lipman, Thomas
TBI Study HREC/14/QRBW/7A Comparison of the Total and Free Cortisol Response to a Standard Short Synacthen Test in Patients with Traumatic Brain InjuryCohen
The free cortisol response to synacthen and other aspects of endocrine physiology in healthy participantsCohen, Nethathe
TRANSFUSE TRANSFUSE STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive carE–a randomised controlled trial. Multi-centre randomised double blinded phase III trial of the effect of standard issue red blood cell blood units on mortality compared to freshest available red blood cell unitsReade
Beta Blockers in BurnsMuller, Paratz
Exercise Testing in the Chronic Critically IllParatz
Investigation of Right Heart Function in Inhalation InjuryParatz
Saline Installation During PhysiotherapyParatz
Sepsis Follow Up ClinicParatz, Boots
National study of family experiences of organ and tisue donationData exchange study -follow up of families who declined organ donationWiddicombe
Trauma and Bicycle InjuryQuality of trauma data for understanding serious bicycle-related injuries in Brisbane and Darwin: Comparing circumstances, patterns, treatment, severity, costs and outcomes of serious cycling injuryHolley
EPPICS IIILipman, Fourie

For more information about our studies, please email our Research team